Excerpt of study published in J Am Coll Cardiol 2008;52:843-850: Oxidative stress is increased in atherosclerotic lesions and might play an important role in plaque progression and calcification.
Methods: Superoxide (dihydroethidium fluorescence and lucigenin-enhanced chemiluminescence), hydrogen peroxide (H2O2) (dichlorofluorescein fluorescence), and expression and activity of pro- and antioxidant enzymes were measured in normal valves from hearts [...]